20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)-
Bulleyaconitine A
CAS: 107668-79-1
Molecular Formula: C35H49NO9
20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- - Names and Identifiers
20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- - Physico-chemical Properties
| Molecular Formula | C35H49NO9 |
| Molar Mass | 627.76 |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Melting Point | 160~165°C |
| Boling Point | 690.9±55.0 °C(Predicted) |
| Solubility | Easily soluble in ethanol, chloroform, and ether, insoluble in water; easily soluble in dilute hydrochloric acid and dilute sulfuric acid. |
| Appearance | White powder |
| pKa | 13.12±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD01714791 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the root tuber, Aconite, Aconite. |
20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- - Reference
| Reference Show more | 1. Sun Tian, LV Yechao, Tang calf, et al. Anti-inflammatory effect and related mechanism of aconitine A on LPS induced RAW264.7 cells [J]. Journal of Taishan Medical University, 2020, 041(005):321-327. 2. [IF = 4.749] Hao Chen et al.Injectable Erythrocyte Gel Loaded with bulayaconitine A for the Treatment of Rheumatoid Arthritis.Acs Biomater Sci Eng. 2021 |
20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- - Reference Information
| Overview | aconitine A is an alkaloid extracted from Aconitum, has a strong analgesic and obvious anti-inflammatory effect, the analgesic effect of this product is central, and is closely related to the level of serotonin in the brain, analgesic effect of morphine 1.75~2.27 times, and no addiction; At the same time this product has antipyretic and local anesthetic effect. |
| effect | 1. Analgesic effect-it is suitable for the unique analgesic mechanism of single or combined drugs, avoid common side effects of opioids and NSAIDs, such as addiction, gastrointestinal damage, etc. 2, anti-inflammatory effect: by inhibiting the chemotactic effect of MCP1, C3a, C5a, regulating autoimmune reaction, on the other hand can reduce the level of PGE2 in serum. 3, immune regulation: by inhibiting the secretion of NO by macrophages, thereby inhibiting endotoxin, TNF-alpha, IL-1, IL-6 and other pathological effects. |
| mechanism of action | Bulleyaconitine A Tablets is a state-dependent sodium channel blocker, which has strong analgesic and obvious anti-inflammatory effects, the analgesic effect of this product has both central and peripheral effects. The analgesic mechanism is to block pain conduction and is closely related to the level of serotonin in the brain. The onset time is slower than morphine, but the maintenance time is long, no addiction; Its anti-inflammatory effect does not pass through the adrenal system, but is related to the inhibition of PG level in the pain area, thus avoiding the gastrointestinal side effects of non-steroidal anti-inflammatory drugs; at the same time this product has antipyretic and local anesthetic effect. |
| toxicity | aconitine A has high acute toxicity, the toxicity of the Diester alkaloids contained in the root of kusnezoffii mainly stimulates the nervous system (especially the vagus nerve and sensory nerve), first excites and then inhibits, and has a direct effect on the myocardium (clinically, the main manifestation is arrhythmia, ECG showed supraventricular and ventricular extrasystoles, atrioventricular block, S-T segment changes, etc.), may be due to respiratory or myocardial paralysis and death. |
| biological activity | bulayaconitine A is a compound isolated from Aconitum plants that has both analgesic and anti-inflammatory activity. |
| Use | aconitine A has anti-inflammatory and analgesic effects. for content determination/identification/pharmacological experiments and other pharmacological effects: suitable for the treatment of advanced cancer pain, rheumatism and rheumatoid arthritis, scapulohumeral periarthritis, shoulder and arm pain, stiff neck, osteoarthritis, benign Arthralgia, lumbar and limb joint sprain, contusion, lumbar muscle strain and low back pain, sciatica, myofibritis and costal cartilage inflammation, herpes zoster, cold Head Pain, toothache, etc. |
Last Update：2024-04-09 02:00:12
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